Recap –
The
Pharmacopoeia is a official book issued under authority of government which
usually contains list and formulae of drugs with their preparations and
properties and the standards to be assigned to be pure.
The first
Indian Pharmacopoeia (I.P.) was published in the year 1955.
The
chronology of I.P.
a. First edition in 1955
b. Second edition in 1966
c. Third edition in 1985
d. Fourth edition in 1996
e. Fifth edition in 2007
f. . Sixth edition in 2010
g. Seventh edition in 2014
To be
continued……
· List
of common Pharmacopoeia and other standard reference books used in India :-
1 Indian Pharmacopoeia
2. British Pharmacopoeia
3. International Pharmacopoeia
4. United states Pharmacopoeia
5. Japanese Pharmacopoeia
6. Chinese Pharmacopoei
7. Martindale extra Pharmacopoeia
8. National formulary
9. Indian Pharmaceutical codex (IPC)
10.
United
states dispensary
There are huge number of official books issued by government.
· The history of Indian Pharmacopoeia (I.P.)
The
government of India directed the Drug technical advisory board (D.T.A.B.) to
list the drugs that are used in India which is not mentioned in British
Pharmacopoeia and also recommend the standards that has to be governed for
their purity.
The Indian
Government published Indian pharmacopeial list in 1946 as a supplement to B.P.
It led to
huge misleading in its title as it not only contain the substantial valued
drugs but also laid down its standards.
The Indian
pharmacopoeial list contains about 180 monographs out of which approximately
100 were grown in India and their galenical, eg berberi ,cassia, bael,
cannabis, raulwalfia, chaulmoogra, ajowan, kurchi, kandala,etc.
The
appendices give number of determinations referred to monographs.
The
pharmaceuticals and drugs research committee to the council of The scientific
and industrial research in Feb. 1947 compiled a brochure for the drugs that
were indigenous in India. Later on it was decided to prepare a codex instead of
brochure on lines of British pharmaceutical codex.
The
government of India on 23 november 1948 elected 11 members from Indian
pharmacopoeial committee for the preparation of Indian pharmacopoeia.
In compiling
the first edition of Indian Pharmacopoeia all vital information were taken from
scientific books like international pharmacopoeia, British pharmacopoeia, etc.
The first
edition of Indian pharmacopoeia were compiled and the first edition of I.P.
were published in year 1955.ber of authorized books issued by government.
· Salient features of first edition of
I.P. :-
I.
The
language used were mostly Latin.
II.
The
measures were in metric system.
III.
Doses
are expressed in both metric as well as imperial system.
IV.
The
list of preparation were given at the end of some monographs.
V.
The
temperature were mostly in thermometric centigrade ©
VI.
The
solubility expressions like freely soluble, slightly soluble, insoluble, etc
were not known.
- As the time passes various amendments and upgradations were done in that case and after every five years new edition of pharmacopoeias were published.
· Salient features of fourth edition of
I.P. :-
I.
Computer
generated formula.
II.
It
contains 1149 monographs and 123 appendices.
III.
I.R.
and U.V. absorption spectroscopic tests were introduced.
IV.
Bacterial
endotoxins have more used for qualitative tests as compared to pyrogen tests.
V.
Minor
monographs along with its dosage forms have been introduced like eye drops
,ointments, pessaries, etc.
VI.
Monograph of ORS were dropped due to
stability.
VII.
Biological
assays were introduced for vaccines, hormones, blood products.
VIII.
Commonly
accepted names were used in monographs for eg :- scopoalamine hydrobromide had
been changed for hyoscine hydrobromide.
This was the whole information about Indian Pharmacopoeia.
In the next blog we shall cover the classification of dosage forms.
Till then signing off Sarang More.
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