Before diving into dosage form, it is very important
to understand what is mean by drug, dosage form, dose, pharmacy, pharmacology,
pharmacognosy, etc.
· Basic
definitions of Dosage forms :-
DRUG:-
A drug is defined as chemical agent intended for
the use in diagnosis, mitigation, prevention, cure and treatment of diseases in
man or animal. (Drug and cosmetic act 1938).
According to WHO “the drug is any substance
or product that is used or is intended to be used to modify or explore
physiological system or pathological states for the benefit of recipient”.
DOSAGE FORM :-
Dosage form is a transformation of a pure
chemical compound in a predetermined form by admixing drug components into non
drug components.
DOSE :-
A specific quantity of drug or medicine
prescribed to be taken in one time or stated intervals.
PHARMACY :-
It is a art and science of compounding and dispensing drugs or preparing suitable dosage forms for administrating man and animals.
It includes collection, identification, purification,
isolation, synthesis and standardization of drugs.
So here the question arises…. Why there is so
important to compound the drug into dosage forms.
Q. Why there is need of dosage forms?
DOSE :-
A specific quantity of drug or medicine
prescribed to be taken in one time or stated intervals.
PHARMACY :-
It is a art and science of compounding and
dispensing drugs or preparing suitable dosage forms for administrating man and
animals.
It includes collection, identification, purification,
isolation, synthesis and standardization of drugs.
So here the question arises…. Why there is so
important to compound the drug into dosage forms.
Q. Why there is need of dosage forms?
DOSE :-
A specific quantity of drug or medicine
prescribed to be taken in one time or stated intervals.
PHARMACY :-
It is a art and science of compounding and
dispensing drugs or preparing suitable dosage forms for administrating man and
animals.
It includes collection, identification, purification,
isolation, synthesis and standardization of drugs.
So here the question arises…. Why there is so
important to compound the drug into dosage forms.
Q. Why there is need of dosage forms?
- i. ACCURATE DOSE :-
There is need of time to deliver the accurate dose to
the patient. If the patient is suffering from high fever up to 102F then
paracetamol 650mg must be delivered because it will work as antipyretic and cools
down the temperature of the patient, if 500mg paracetamol must be administered
then it will not much effective to him.
i. PROTECTION FROM ENVIRONMENTAL FACTORS :-
The drug is in pure form.so if we administered it in
pure form the body will respond it aggressively and the adverse effect will
occur.
The need of transforming into a dosage form is to
protect the API (active pharmaceutical ingredient ) from gastric juices.
Some drugs are hygroscopic and deliquescent in nature,
so to protect it from atmospheric conditions it is crucial to compound it in a
required dosage form.
Eg- the enteric coated tablets which are tend to be
dispersed in intestine unfortunately gets destroyed in stomach, the enteric
coating helps it from attack in stomach by HCl liquid.
i.
MASKING THE UNPLEASENT TASTE
AND ODOR :-
Certain drugs which is bitter in taste withdraws the
consumption by the patient.
The low
consumption of drugs will not be beneficial for the patient.
Eg- the
paediatric drugs are commonly delivered with flavours for increasing appetizing
of the small babies and also encourage them to take the medicines.
ii.
OPTIMAL DRUG ACTION :-
There are
certain drugs which are given in very small quantity like antidepressants in
the variation of 1mcg. So to deliver the drugs which are very minute to
administer so they are compiled in suitable dosage form.
Eg-
chlordiazepoxide which is known as antidepressants is given in 1-2 mcg which is
very minute in quantity so it is necessary for them to convert them for their
maximum action.
i.
SUSTAINED RELEASED MEDICATION :-
The drugs
which are easily excretable must be combined with certain other excipients
which are hard to metabolised so the conversion of these drugs is crucial.
Eg- enteric
coated tablets which dissolved in stomach which must be dissolved in intestine.
ii.
CONTROLLED RELEASED MEDICATION :-
There are
certain drugs which requires controlled releasing of the drugs or requires
prolong effect. So converting them into suitable dosage form is very
beneficial. The prolongation release of drugs results the low intake of drugs
which will not form any habit in the patient and the drugs will be released
according to the intensity and need of that drug. This smart way of releasing
of drug help to utilize the drug to its full extent and can gets less first
pass metabolized.
Eg- Nicotine
patches which are used for smoking addictive’s is very beneficial.
i.
INSERTION OF DRUGS ONTO BODY CAVITIES :-
A handful
quantity of drugs are target specific ( those drugs which are acting on
specific sites rather than whole body ) so it is very crucial for that drug to
reach that specific site without any kind of changes.
Eg-
insufflations which are meant to be acting in specific sites reach to that site
by using a device known as ‘insufflator’.
i.
PLACEMENT OF DRUGS WITHIN BODY TISSUES:-
As we
discussed earlier that certain drugs are target specific, so the proper
delivery of that drug will enhance the effectiveness and action of that drug up
to mark.
In a nutshell we can conclude the need of dosage form as follow-
1. |
Accurate Dose |
2. |
Protection from environmental factors |
3. |
Masking taste and odour |
4. |
Optimal drug action |
5. |
Sustained released action |
6. |
Controlled released medication |
7. |
Insertion of drugs into body cavities |
8. |
Placement of drug into body tissues |
In the next blog we will cover the huge classification of the dosage form and its definition.
Till then signing off Sarang More...... will meet you next blog.
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